Respond Tatyana Stepanova, a gastroenterologist, hepatologist required instructions Antigep - human immunoglobulin against hepatitis B Antigep is a concentrated solution of purified immunoglobulin fractions, isolated by the alcohol from the blood plasma of donors immunized with recombinant hepatitis B vaccine. Plasma of each donor is tested for the absence of surface antigen of hepatitis B virus (NBsAg) and antibodies to HIV-1 and HIV-2 and hepatitis C. The protein concentration in the preparation of 10 to 16%. The concentration of antibodies to surface antigen of hepatitis B virus is not less than 50 IU / ml. Product does not contain a preservative or antibiotics. Transparent or slightly opalescent liquid, colorless or weak yellow color. During storage allowed the emergence of low precipitation in white, disappearing with shaking at room temperature. Immunological properties. The current starting drugs are antibodies to surface antigen of hepatitis B virus (NBsAg), which block the receptors of the virus. The maximum concentration of antibodies in the blood is reached after 24 hours, during their half-life is 4-5 weeks. Purpose. Emergency prevention of hepatitis B in children and adults, treatment of light and medium-severe forms of acute viral hepatitis B in adults. Method of application and dosage. Immune globulin is administered intramuscularly in the upper outer quadrant of the gluteal muscles or the outer surface of the thigh. Prior to the injection vial with the preparation incubated for 2 h at room temperature. Opening of the vials and the procedure of introduction is in strict compliance with the rules of asepsis and antisepsis. Drug store in unopened vials can not be. Do not be suitable for use in injectable products from tampering with or labeling, a change in physical properties (color change, turbidity, presence nonseparating sediment), with expiration date, if improperly stored. To avoid foaming agent recruited into the syringe needle with a wide lumen. Prevention. Dose and the multiplicity of its introduction depends on indication for use: - infants from their mothers - HBsAg carriers or patients with acute hepatitis B in the period of delivery entered a dose (100 ME) in the first 12 hours after birth along with hepatitis B vaccine, but different parts of the body (in the future children to be vaccinated hepatitis B vaccine at the age of 1, 2 and 12 months) - persons not previously vaccinated against hepatitis B or persons whose vaccination is not completed, or when the level of NVs antibodies below security (less than 10 IU / L) after random infections through contact with infectious material (for injections, dental procedures, blood transfusions, splashes of infected material into the mouth or eyes, etc.), the drug is administered at the rate of 0.1 ml / kg as soon as possible after exposure (preferably within 24 - 48 hours). At the same time (on the same day) should begin (continue) vaccination against hepatitis B according to the scheme 0-1-2-12 months. - Persons belonging to groups at high risk of infection with hepatitis B virus (chronic hemodialysis patients centers, patients suffering from different diseases, which according to the life receive frequent transfusions of blood and its products, contact centers in hepatitis B, etc.), not vaccinated against hepatitis B B immune globulin is administered before the procedure - hemodialysis, transfusion of blood and blood products, etc., for children up to 10 years - 100 ME, children over 10 years and adults - a rate of 0.1 ml / kg. Simultaneously with the introduction of immunoglobulin should start a course of hepatitis B vaccination in the truncated scheme - 3 applications of the vaccine with an interval of 1 month. 12 months after immunization began introduces fourth additional dose of vaccine. The first dose of vaccine administered simultaneously with intravenous immunoglobulin, but in different parts of the body. By drinking large amounts (more than 5 ml) of the drug is recommended to introduce the required amount in different parts of the gluteal muscles. The drug is administered only by a physician (medical assistants). Immunoglobulin registered in accordance with accounting forms indicating the serial number, issue date, expiry date, manufacturer, date of administration, dose, reaction to the introduction. Treatment. With the therapeutic goal Antigep - human immunoglobulin against hepatitis B is prescribed in the first five days of onset of jaundice period of viral hepatitis B. The drug is administered in a single dose of 0.1 ml / kg body weight daily for 3 days. Reactions to the introduction, as a rule, are absent. In rare cases may develop local reactions such as redness, fever up to 37.5 C during the first days after administration. In individuals with altered reactivity may develop allergic reactions of various types, and in extremely rare cases - anaphylactic shock, and therefore the person who received the drug should be kept under medical observation for 30 minutes. Places of vaccination must be provided with the means of antishock therapy. Contraindications. Contraindicated for the introduction of human immunoglobulin against hepatitis B, persons who had a history of severe allergic reaction to the administration of drugs in human blood. If there is a history of clinically significant allergic reactions in the day of administration of immunoglobulin and for the next 3 days, recommended the appointment of an antihistamine. Persons suffering from immunopathological systemic diseases (diseases of blood, connective tissue, jade, etc.), the drug should be administered against a background of appropriate therapy. Caution. Vaccinations against measles, mumps and rubella is not earlier than 2 months after the introduction of human immunoglobulin against hepatitis B. The form of release. In ampoules of 2 ml - 1 dose no less than 100 ME antibodies NBsAg. The package contains 10 vials. Conditions of storage and transportation. The drug is stored and transported at 2 to 8 ° C in accordance with the joint venture 3.3.2.1248-03. Shelf life. 2 years. Shelf life - 2 years. Available on prescription. Similar question: ... normanno all vaccinations done. Tell me please: ... treatment I need to spend? You can ...
No comments:
Post a Comment